For the emergency treatment of known or suspected opioid overdose

Naloxone Hydrochloride Nasal Spray from Amneal

An FDA-approved generic equivalent for Narcan® (naloxone HCl) Nasal Spray.

Now available over-the-counter, without a prescription.

Amneal Naloxone HCl Nasal Spray has the same active ingredient and works in the body the same way as Narcan® Nasal Spray. Naloxone Nasal Spray is for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

Naloxone HCl Nasal Spray should be used immediately if signs or symptoms of an opioid overdose are present. An opioid emergency can cause severe injury or death, so swift action is crucial. Learn more about the signs and symptoms of an opioid emergency here.

Amneal Naloxone HCl Nasal Spray is available in a carton containing two blister packages, each containing a 4 mg single-spray device.

Learn how to use Amneal Naloxone Nasal Spray

Learn the correct administration of this lifesaving opioid overdose reversal treatment by watching the short instructional video or visiting the How to Use page.

Play Video

How to use Naloxone HCl Nasal Spray

Amneal Naloxone Hydrochloride Nasal Spray is available without a prescription

Amneal Naloxone HCl Nasal Spray is available without a prescription at most major pharmacies across the U.S. If you or a loved one show signs of opioid addiction or regularly take opioids, talk to your pharmacist about keeping Amneal Naloxone HCl Nasal Spray on hand in case of an opioid emergency.

An FDA-Approved generic equivalent for Narcan® (Naloxone HCl) Nasal Spray

Amneal Naloxone HCl
Nasal Spray

Nasal Spray.

Contains the same active ingredient
(naloxone hydrochloride)

Route of administration
(nasal spray)

Same indication (for the emergency treatment of suspected opioid overdose)

Naloxone HCl Nasal Spray can cause serious side effects.

In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving naloxone hydrochloride nasal spray and may include:

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of Naloxone HCl Nasal Spray. Call your doctor for medical advice about side effects. To report an adverse event related to an Amneal product contact Amneal Drug Safety at 1-877-835-5472, option 3 or at You may also contact the FDA by visiting, or calling 1-800-FDA-1088.

Amneal is dedicated to increasing patient access to affordable generic medications worldwide.

With over 20 years of experience, our generics business is among the largest in the U.S. We believe that everyone deserves access to high-quality healthcare, and our commitment to producing safe, effective, and reliable generic drugs is an essential part of achieving that goal.

Amneal is proud to supply the state of California with affordable access to life-saving naloxone through its CalRx program. Click here to learn more.